In healthy eyes, the accuracy and interchangeability of corneal tomography measurements obtained by Galilei G6 and Pentacom HR systems are compared

Purpose: To compare the accuracy and interchangeability of anterior segment measurements obtained using the Galilei G6 and Pentacam HR systems in healthy eyes. Methods: This cross-sectional study involved 51 right eyes from 51 healthy participants (age range: 19–47 years). Three consecutive scans were performed on each eye using both systems. Key parameters measured included keratometry (K1, K2), central corneal thickness (CCT), anterior chamber depth (ACD), and corneal volume (CV). Intraclass correlation coefficients (ICCs) and Bland-Altman plots were used to assess measurement agreement. Results: The mean age of participants was 29.0 ± 8.4 (range,19-47)years(male/female =20/31). Significant differences were observed in K1 (P = 0.038) and CCT (P < 0.001), while ACD showed no statistically significant difference (P = 0.177). Bland–Altman plots revealed wide limits of agreement for CCT and keratometry, indicating limited agreement that may affect clinical interchangeability for these parameters. K1 measurements were interchangeable within ±0.25 D (clinically acceptable margin), while CCT measurements showed differences exceeding the ±10 μm clinically acceptable threshold. ACD showed moderate variability, suggesting limited interchangeability between the devices for this parameter. The results highlight the importance of considering device-specific measurements for clinical decision-making. Conclusion: K1 measurements from the Pentacam HR and Galilei G6 systems showed close agreement within ±0.25 D in healthy eyes, suggesting reasonable consistency for clinical assessments. However, differences in CCT and ACD measurements exceeded clinically acceptable limits, indicating that these parameters should not be used interchangeably. As the study was limited to healthy eyes, the findings should be interpreted with caution and may not directly apply to patients with corneal irregularities or a history of ocular surgery. Future studies should investigate the performance of these devices in more diverse patient populations to assess broader clinical applicability.