Formulation and Evaluation of Pioglitazone Hydrochloride and Teneligliptin combined Nano suspension for diabetes

Many recently developed drugs exhibit reduced water solubility, which causes problems with bioavailability. The application of conventional methods for improving solubility remains limited, particularly when a drug has low solubility in both aqueous and non-aqueous solvents. Nano suspension technology has therefore shown to be a novel and profitable method of increasing the bioavailability of poorly soluble drugs. In the present study, we combined the anti-diabetic effect of pioglitazone hydrochloride and Teneligliptin preparing a hybrid Nano suspension with high efficiency, low toxicity, and enhanced efficacy to achieve the purpose of synergism and enhanced clinical beneficial. The Prepared Nanosuspension was evaluated for different parameters like Appearance, Redispersibiility, Viscosity, pH, Drug content. The results of stability study were confirmed that the prepared pioglitazone hydrochloride and Teneligliptin Nano suspension is stable during the stability study. Thus, it can be concluded that the combined Nano suspension method was commercially feasible and cost effective.