FMTdb: An Integrated Database of Clinical and Microbial Profiles for Fecal Microbiota Transplantation

Functional gastrointestinal disorders (FGIDs) are prevalent and burdensome, yet progress in microbiota-targeted therapies such as fecal microbiota transplantation (FMT) has been hampered by the lack of large-scale, integrated datasets. Current studies are mostly limited in sample size and scope, constraining mechanistic insight and precision application. To fill this critical gap, we established FMTdb, the first and largest disease-specific database dedicated to FGID patients treated with FMT. This resource integrates demographic, clinical, and multi-omic microbiota data from 15 rigorously screened long-term donors, 370 FGID recipients, and 2,008 healthy community controls. Importantly, longitudinal metadata include donor follow-up and pre/post-treatment outcomes of recipients, enabling dynamic assessment of efficacy and safety. By providing a multi-layered dataset that connects microbial composition with host response, FMTdb offers a robust platform for biomarker discovery, mechanistic exploration, and the development of personalized microbiota-based interventions for FGIDs.