Nutrigenomics Research from 1960 to 2024: A Systematic Review and Bibliometric Analysis of Global Trends and Research Gaps

Nutrigenomics is at the intersection of genetics, nutrition, and health and has changed how dietary interventions are personalized based on genetic profiles. Since the completion of the Human Genome Project, this emerging field has sought to understand nutrient–gene interactions and how they influence disease risk and prevention, particularly in the context of non-transmissible chronic diseases (NTCDs). This study presents a systematic literature review and bibliometric analysis of nutrigenomics research published from 1960 to 2024. Using the Scopus database, 4,314 documents were initially retrieved. After language and document-type filtering, and subsequent manual keyword screening, 878 relevant publications were analyzed. Bibliometric tools including Bibliometrix in R and VOSviewer were used to map authorship networks, keyword co-occurrence, and thematic evolution. Results show that nutrigenomics remains a young but growing field, with an average annual growth rate of 4.71 percent. The United States leads in publication volume, followed by Italy and Spain. However, major gaps still persist; including underrepresentation of diverse populations, limited gut microbiome studies, insufficient translational research, and lack of standardized methodologies. African contribution remains limited, with only 29.5 percent international collaboration. Addressing these gaps is essential to developing globally relevant, genomically informed nutrition strategies.