Alzheimer’s Disease blood biomarkers measured through remote capillary sampling correlate with cognitive performance in older adults
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Blood biomarkers are rapidly becoming established in the diagnostic pathway for Alzheimer’s Disease (AD), particularly p-tau217. However, there is a need for more scalable detection tools to reach individuals who are not in contact with specialist healthcare services. A recent study validated a capillary blood sampling technique for detection, quantification and diagnostic utility of p-tau217. This study examines the potential clinical utility of this technology. Correlation analysis shows robust associations between capillary p-tau217 and measures of cognition and function. A pre-specified (85%) p-tau217 specificity threshold also demonstrates good performance in identifying the 20% of patients with highest risk of AD pathology and delivers significant separation in cognition and function in patients above and below the identified p-tau217 threshold. Patient feedback indicates high acceptability and usability of the capillary test method, giving confidence in the feasibility of this technology for widescale adoption. The study demonstrates the potential utility of remote p-tau217 to improve triage of patients into clinical services and trials.
