Assessment of Cerebral, Renal, and Hepatic Tissue Oxygenation Changes in Neonates Given Fresh Frozen Plasma

Background: This study aimed to evaluate changes in cerebral, hepatic, and renal tissue oxygenation in neonates receiving fresh frozen plasma (FFP) via near-infrared spectroscopy (NIRS) and to assess correlations with vital signs and laboratory parameters. Methods: This single-center prospective observational study was conducted in a neonatal intensive care unit and included neonates who received fresh frozen plasma (FFP) infusion. Cerebral (right and left), hepatic, and renal tissue oxygenation were continuously monitored via a four-channel near-infrared spectroscopy (NIRS) device during FFP infusion and for six hours thereafter. In addition, body weight, birth weight, exposure to prenatal steroids, sex, postnatal age, hemoglobin concentration, blood gas parameters, blood glucose levels, and vital signs were recorded for each patient. Results: Twenty-four infants (gestational age 24–41.2 weeks) were included. No significant changes were observed in cerebral or hepatic tissue oxygenation after FFP infusion. However, renal tissue oxygenation significantly increased at hour 2 compared with that at hour 1 and at hour 6 compared with that at hours 0 and 5. A positive correlation was also found between changes in the left cerebral and hepatic NIRS values over the 6-hour period. Conclusion: While FFP infusion did not significantly alter cerebral or hepatic oxygenation, it was associated with improved renal NIRS values, suggesting a selective positive effect on somatic perfusion. Moreover, the observed correlation between cerebral and hepatic NIRS changes indicates that FFP may exert parallel effects across cerebral and somatic regions.