Influence of MMP12 single nucleotide polymorphism rs586701 on the prognosis of primary lung cancer patients：a multicenter prospective study

Purpose Lung cancer is a common cancer, with a high mortality rate and poor prognosis. Predicting the prognosis of lung cancer patients and using this information to develop treatment strategies and interventions is important for prolonging patient survival. Methods Blood samples were collected from 839 patients diagnosed with lung cancer, and genomic DNA was extracted for genotyping using SNPscan technology. In order to adjust for multiple factors, the data was stratified by age, sex, smoking status, family history, TNM stage and cancer tissue type. The association between lung cancer prognosis and genotype was then analyzed using a multivariate Cox proportional risk model. Results A polymorphism in the MMP12 gene, the T > G variant at position 586701, has been associated with a worse prognosis. Patients with the TG genotype (TG vs TT, HR = 1.21, 95% CI: 1.01–1.44, P = 0.035) exhibited a worse prognosis. Stratified analyses showed that among male, younger than 60 years old and smoking patients, patients with the TG genotype had a lower survival time (HR = 1.24, 95% CI: 1.01–1.52, P = 0.04; HR = 1.58, 95% CI: 1.18–2.12, P = 0.002; HR = 1.30, 95% CI: 1.06–1.61, P = 0.013). In patients with SCC and NSCLC, survival time was shorter with the TG genotype (TG vs TT, HR = 1.48, 95% CI: 1.10–2.01, P = 0.010; HR = 1.21, 95% CI: 1.01–1.46, P = 0.038). In the designed genetic model, the dominant genotype TG + GG was associated with worse prognosis among patients aged less than 60 years (TG + GG vs TT, HR = 1.43, 95% CI: 1.07–1.90, P = 0.014). Conclusion The MMP12 polymorphism rs586701 T > G may be associated with a worse prognosis of lung cancer.