Cardioprotective effects of Galangin in Adenine-induced Chronic Kidney Disease rats

Chronic kidney disease is highly associated with cardiovascular diseases such as cardiac hypertrophy, dysfunction and fibrosis. Galangin, a flavonoid naturally found in herbs used in traditional medicine possess various pharmacological activities. This study aims to evaluate the cardioprotective effect of galangin in CKD rats. SD rats were randomly divided as follows. Rats in Group 1 received 0.5% CMC (Normal control), Group-2 received Adenine 200 mg/kg (CKD control), Group-3 received Losartan 20 mg/kg, Group-4 received Galangin 20 mg/kg, Group-5 received Galangin 40 mg/kg. The rats were treated with the above drugs for 4-weeks. The rat kidney function, cardiac oxidative stress, cardiac hydroxyproline and histological studies were performed. Galangin has significantly reduced heart weights, serum cardiac markers, cardiac SOD, lipid peroxidation, hydroxyproline formation and alterations in cardiac morphology that were altered in CKD.