Simbiology®-Driven PK-PD Modeling of Exosome (miR378) Delivery to Reduce Collagen Overproduction in Cardiac Fibrosis
Discuss this preprint
Start a discussion What are Sciety discussions?Listed in
This article is not in any list yet, why not save it to one of your lists.Abstract
Cardiac Fibrosis lacks consistent and reliable treatment utilizing drugs such as ACE inhibitors, coagulants, and ARBS. As modeling and simulation are increasingly being used in drug development for pharmacokinetic-pharmacodynamic (PK-PD) relationships to support preclinical research, I simulate an extracellular vehicle (EV) called an exosome modified with miR378 to reduce collagen buildup that causes Cardiac Fibrosis (CF), which occurs in the cardiac interstitium of heart tissue. Using the Simbiology® graphical user interface (GUI), I perform a bolus dose, a pulsed dose, and a binding + maintenance dose. I demonstrated presentational pathway figures, parameters, species estimation, and thermodynamic binding affinities. The results show that the bolus doses and multiple pulse doses have significantly successful results in stopping fibrotic collagen production conditions in the interstitial space.
