Home-Based Deep Sleep Modulation in Parkinson’s Disease: Extension Study on Long-Term Feasibility and Sleep-Related Outcomes

  1. Jana Horlacher
  2. Nora-Hjördis Moser
  3. Simon J. Schreiner
  4. Renske Sassenburg
  5. Lydia Kämpf
  6. Sophia D. Schibler
  7. Valentino Mutschler
  8. Esther Werth
  9. Philipp Valko
  10. Jelena Skorucak
  11. Laura Ferster
  12. Walter Karlen
  13. Reto Huber
  14. Christian R. Baumann
  15. Angelina Maric
Read the full article See related articles

Discuss this preprint

Start a discussion What are Sciety discussions?

Listed in

This article is not in any list yet, why not save it to one of your lists.
Log in to save this article

Abstract

This study assessed feasibility and effects of a randomised two-week, at-home intervention with phase-targeted auditory stimulation (PTAS) of slow waves in Parkinson's disease (PD). We reproduced previously reported enhancement of slow wave activity and confirmed indications of improved patient-reported outcomes. Together with the high adherence and data quality, this suggests that home-based PTAS protocols are a feasible method for investigating the long-term therapeutic potential of deep sleep enhancement in PD.

Article activity feed

  1. Version published to 10.21203/rs.3.rs-7829414/v1 on Research Square