Brainy2Blessly and QEEG: A Neurofunctional Window into Schizophrenia Rehabilitation

Introduction: The integration of digital tools and neurophysiological monitoring in mental health care presents new opportunities for cognitive and motor rehabilitation. This study investigated the Brainy2Blessly (B2B) app as a tool for assessing visuospatial prioritization and emotional habituation related to physical activity in individuals with schizophrenia. Simultaneous brain mapping was conducted to explore neurocognitive engagement and motor relearning. Methods: Thirty participants with schizophrenia (mean age = 38.9 ± 7.15 years) completed structured tasks using the B2B app under two conditions: with and without quantitative EEG (QEEG) monitoring. Percentages of top-ranking physical activities linked to “happy hormones” were calculated based on energy expenditure data from the Thai Physical Activity Guideline. QEEG measured theta relative power, beta relative power, and the theta/beta ratio at six scalp locations during task performance. Results: QEEG data revealed region-specific neural activation during the B2B and LCAR tasks. Theta relative power was highest at Fz, followed by Cz and F4, indicating robust engagement of executive and motor-planning regions. Theta/beta ratios peaked at Fp1 and Fz during calm states, reflecting prefrontal regulation and internal attention. Frontal beta power at F4, F7, and Fz showed moderate positive correlations with dopamine-, serotonin-, and endorphin-linked physical activity phases, suggesting sensitivity to reward, affective, and executive functions. Notably, the Fp1 theta/beta ratio was positively associated with serotonin-related calmness, while T3 beta power exhibited low correlations with oxytocin and serotonin, indicating diminished social-affective engagement. ANOVA results confirmed significant differences in EEG indices across sites (F = 28.57–38.29, p < .001), supporting the site-specific neurofunctional relevance of QEEG-informed occupational performance. Conclusion: QEEG-guided occupational tasks reveal distinct neural engagement patterns linked to emotional and executive functions in schizophrenia. These findings support the use of Brain Mapping Performance (BMP) and the B2B app as valuable tools for individualized rehabilitation planning in occupational therapy.