Coexistence of diffuse large B cell lymphoma and lung adenocarcinoma in one lymph node: a case report and literature review
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Older males demonstrate heightened susceptibility to both diffuse large B-cell lymphoma (DLBCL) and lung adenocarcinoma. Nevertheless, synchronous presentation of DLBCL and adenocarcinoma within the same lymph node remains exceptionally rare. We report a case of a 70-year-old male patient in whom histopathological examination of a lymph node revealed co-existing DLBCL (non-germinal center B-cell subtype) and metastatic lung adenocarcinoma components. The patient received four cycles of R-CHOP immunochemotherapy (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone), achieving disease stabilization with no progression observed at five-month follow-up. This unusual coexistence of DLBCL and metastatic carcinoma poses a significant diagnostic challenge, underscoring the critical need for precise early histopathological evaluation to guide optimal therapeutic intervention.
