Comparison of Mechanical Properties between Concentrated Growth Factor Membranes and Bio-Gide Absorbable Barrier Membranes

Aims This study aimed to systematically compare the mechanical properties of concentrated growth factor (CGF) membranes and absorbable biological membranes, focusing on Young’s modulus, maximum tensile strength, and tensile strain at break. Methods Ten volunteers provided 9 mL venous blood samples, which were centrifuged using a Medifuge device to isolate CGF. The resulting fibrin block was compressed into membranes measuring 5 mm × 50 mm × 0.5 mm and stored in a solution of 0.9% saline. Commercial Bio-Gide membranes were cut into identical dimensions (N = 10 per group). Tensile tests were conducted under controlled conditions (25 ± 3°C, 50 ± 25% humidity) with a clamp spacing of 20 mm and an initial preload of 0.01 N. Mechanical parameters were derived from the stress-strain curves, and statistical analyses were performed using SPSS version 26.0 employing Shapiro-Wilk test, Levene’s test, independent samples t-test, or Mann-Whitney U test (α = 0.05). Results Results indicated that the average Young’s modulus of CGF membranes was significantly lower than that of Bio-Gide [(14.5 ± 2.3) MPa vs. (16.7 ± 3.5) MPa; P < 0.001], suggesting greater rigidity in Bio-Gide membranes. However, maximum tensile strength did not show statistically significant differences between CGF [(0.52 ± 0.11) MPa] and Bio-Gide [(0.75 ± 0.16) MPa] (P > 0.05). Although Bio-Gide exhibited higher mean tensile strain at break, no significant difference was observed between the two materials (P > 0.05). Conclusion These findings suggest that while CGF membranes possess lower rigidity compared to Bio-Gide, they demonstrate comparable tensile strength, thereby supporting their potential as alternative or adjunct barrier materials in regenerative procedures requiring mechanical stability and adaptability.