Therapeutic Efficacy of an Herbal Remedy for Feline Chronic Gingivitis-stomatitis FCGS in Feline Calicivirus-positive Cats

Objective: To evaluate the therapeutic efficacy of the herbal remedy Marecipe AV in treating feline chronic gingivostomatitis (FCGS) associated with feline calicivirus (FCV) infection in a real-world setting. Methods: The treatment entailed the oral administration of Marecipe AV as monotherapy. Efficacy was assessed via the analysis of outcomes. These outcomes encompassed clinical remission as well as alterations in viral load both prior to and subsequent to treatment. Results: All 62 cats treated with Marecipe AV monotherapy achieved clinical remission. Both the treatment response rate and the clinical remission rate were 100%. In all of the treated cases, the clinical signs and symptoms induced by FCV, such as drooling and tearing, resolved within 2 to 5 days. Mild to moderate cases achieved complete remission within 7 to 15 days of treatment. Cats with severe ACGS achieved complete remission after an average treatment duration of 63.5 days (ranging from 45 to 85 days). A significant reduction in viral load was observed on day 7 after treatment (mean Ct 30.49 compared to a baseline of 23.90) in all treated cases. By day 15, the mean Ct was 33.87 (close to the detection limit). High recurrence rates were noted. Specifically, in mild to moderate cases, the recurrence rate reached 83.33% at three months. In severe cases where the treatment duration exceeded 45 days, the recurrence rate was 63.63%. In the group that underwent three retreatments with Marecipe AV, the recurrence rates at 3 months and 6 months were both 28.57%. Conclusion: Marecipe AV herbal remedy is an effective treatment for ACGS in cats, demonstrating a remarkable 100% clinical remission. However, the recurrence rates associated with this remedy are high, resulting in many cured cats needing repeated treatments.