Regulome-SNP and Novel Risk Markers of CHD Susceptibility in the Yanbian Area

Background CHD is considered a polygenic complex disease that occurs due to the combined action of genetic and environmental factors. To explore the relationship between four Regulome-SNP loci and susceptibility of patients with coronary heart disease (CHD) in Yanbian area. Methods In total, 600 patients with CHD and 616 healthy controls in the Yanbian area were selected as participants. Genotype and allele distribution frequency were obtained by second-generation sequencing. Binary logistic regression model was used to analyze the relationship between four polymorphisms and genetic susceptibility to hepatocellular carcinoma. Results KEAP1-rs11668429T > G locus negative model was more prone to CHD than TG + GG genotype compared with individuals with TT genotype (adjusted OR = 1.379, CI: 1.077–1.781, P  = 0.011), and the BCR rs2267018A > G locus negative model was more prone to CHD than individuals with the AA genotype (adjusted OR = 1.533, 95% CI: 1.221–1.976, p  < 0.001). In the LTBP1 rs2290449G > A negative model, compared with individuals with GG genotype, the GG + AG genotype was more prone to CHD than the AA + GA genotype (adjusted OR = 1.475, CI: 1.157–1.880, P  = 0.002), and in KIT rs3094165G > A positive model, compared with individuals with AA genotype, GG + AG genotype was more prone to CHD (adjusted OR = 1.759, 95% CI: 1.155–2.679, P  = 0.008). Conclusions Analysis of risk genotype combinations showed that the risk of patients carrying one, two, three, and four dangerous genotype (adjusted OR [95% CI] 1.150 [0.587–2.251] P  = 0.684, 2.075 [1.093–3.941] P  = 0.026; 2.765 [1.392–5.070] P  = 0.003; and 5.683 [2.055–15.718] P =  0.001, respectively) could be used as novel markers to detect susceptibility to CHD.