3D-printed titanium alloy scaffolds combined with platelet-rich plasma injection for the repair of long-segment femoral defects

Objective This study aimed to investigate the clinical efficacy and feasibility of 3D-printed titanium alloy scaffolds combined with autologous platelet-rich plasma (PRP) injection in the treatment of long-segment femoral defects. Methods A retrospective analysis was conducted on 16 patients with long-segment femoral defects who received treatment at our hospital between January 2021 and December 2023. All patients underwent treatment with 3D-printed titanium alloy scaffolds combined with PRP injection. At the final follow-up, treatment outcomes were comprehensively assessed using the Visual Analogue Scale (VAS), the Lower Extremity Functional Scale (LEFS), the Lane–Sandhu score, and patient satisfaction ratings. Results The mean follow-up duration for all patients in this study was 12.63 ± 1.02 months. At the final follow-up, the VAS score was 2.13 ± 1.15, significantly lower than the preoperative score of 6.31 ± 1.74 (P < 0.001). The LEFS score was 54.88 ± 6.01, significantly higher than the preoperative score of 33.81 ± 8.05 (P < 0.001). The Lane–Sandhu score was 7.19 ± 1.38, and the patient-reported satisfaction score was 8.88 ± 1.02. No severe complications were observed during the follow-up period. Conclusion 3D-printed titanium alloy scaffolds combined with PRP injection demonstrated positive clinical outcomes in the treatment of long-segment femoral defects, alleviating pain and enhancing lower limb functional recovery.