Development and Assessment of a Pomegranate Peel-Derived Herbal Gel for Improved Anti-Acne Efficacy and Skin Tolerance

Background Acne is a widespread skin ailment characterized by the growth of pimples, blackheads, and cysts, typically on the face, neck, back, and chest. It originates from blocked hair follicles, oil (sebum) buildup, and dead skin cells, leading to bacterial development and irritation. Herbal formulations have gained appeal due to their safety and efficacy, notably in the beauty business. Pomegranate peels ( Punica granatum ) are rich in antibacterial and antioxidant components, making them appropriate for managing acne. The Main body of the abstract This research focused on developing an herbal anti-acne gel utilizing hydro-alcoholic extracts of Pomegranate peels. Gel was formulated to increase the bioavailability and penetration of the active components. The gel's physicochemical qualities, including pH, viscosity, spreadability, and swelling index, were examined and shown to be suitable for skin application, allowing simplicity of use and effective delivery. The extract was characterized using UV-visible spectroscopy to identify key bioactive compounds. Furthermore, the existence of strong free radical scavengers was confirmed by DPPH tests, which were used to assess antioxidant activity. The anti-inflammatory potential of the gel was assessed through in vitro studies, demonstrating significant inhibition of inflammatory mediators. The gel formulation exhibited substantial antibacterial activity against Propionibacterium acnes and Staphylococcus aureus, surpassing the efficacy of standard Clindamycin. Stability experiments conducted over three months at regulated temperatures (25±2°C and 2-8±3°C) proved the gel's endurance and preserved its physicochemical integrity. This study emphasizes the advantages of using Pomegranate Peel Extract in gel form for acne treatment. Benefits include enhanced bioavailability, potent antioxidant and anti-inflammatory activity, and reduced discomfort. For those looking for safe and efficient acne treatments, the mixture offers a potential natural substitute. Short Conclusion The produced Pomegranate Peel Extract gel revealed remarkable anti-acne effects, stability, and skin compatibility. Its formulation is safe, easy, and efficient, giving substantial potential for application as an anti-acne ingredient in cosmetic and dermatological products.