Assessment of the Efficacy of an Integrated Rehabilitation Program in Relapse Prevention Among Opioid Use Disorder Patients in Psychiatry and Neurology Center, Tanta University

Background Substance use disorders (SUDs), especially opioid dependence, are a significant problem in Egypt. psychological therapies like cognitive-behavioral therapy (CBT) and mindfulness-based cognitive therapy (MBCT) provide effectiveness in reducing relapse and improve the Quality of life (QOL) in patients with SUD treatment. The aim of the study was to develop a structured, integrated rehabilitation program designed for relapse prevention among patients diagnosed with opioid use disorder (OUD), evaluate the efficacy of this integrated intervention in reducing relapse rates, assess its impact on patients’ QOL and identify significant clinical, psychological, and sociodemographic predictors of relapse within patients. Methods This quasi-experimental design was employed to evaluate the efficacy of an integrated rehabilitation program for relapse prevention among individuals with OUD on 100 male patients with OUD as per diagnostic and statistical manual of mental disorders, 5th edition (DSM-5) criteria, aged from 18 to 45 years old. Results The active treatment group showed significantly lower relapse rates in 3 months (P = 0.001) and 6 months (P = 0.001). Addiction severity index (ASI) scores improved markedly in the treatment group across medical, legal, occupational, and psychiatric domains (P < 0.05). QoL scores (physical, psychological, social, environmental) also improved significantly post-intervention (P = 0.001). Survival analysis confirmed the treatment group’s lower relapse risk (P = 0.001), while marital status (single/divorced) predicted higher relapse risk. Conclusions The integrated CBT/MI/with mindfulness rehabilitation program significantly reduced relapses and enhanced QoL in OUD patients compared to standard care. These findings advocate for its applicable in clinical practice.