Formulation of Perindopril Erbumine Loaded Chitosan Nanoparticles for use in Sustaining Drug Release

In this work Perindropil Erbumine (PE) loaded chitosan nanoparticles (CSNPs) with enhanced association efficiency (AE) are formulated and evaluated to improve drug bioavailability in the human body. Ionotropic gelation between sodium tripolyphosphate (Na-TPP) and chitosan resulted in PE loaded chitosan nanoparticles (PECSNPs). FTIR, XRD, SEM, and TEM analyses were used to characterize the nanoparticles (NPs). The AE of PECSNPs were found to be 88%. PECSNPs were shown to have an 88% AE. The TEM investigation confirms that homogenous nanoparticles have formed and the PE molecules have been adsorbed on the surface of the CSNPs. In the instance of in vitro release tests, PECSNPs demonstrated prolonged release of PE following an initial fast release. When PE was released in vitro, PECSNPs demonstrated a prolonged release of PE following an initial fast release. The sustained release of PE from CSNPs is thus occured as PE was adsorbed on their surface. As a result, PE is released from CSNPs over time without encapsulation due to the adsorption of PE on their surface. Therefore, the drug distribution system generated in this manner has the capacity to be a successful and effective drug delivery system.