15 Years of Progress in Quercetin Nanotechnology Revealing Thematic Evolution Applications and Future Directions

Quercetin, a natural flavonoid with notable health benefits and therapeutic properties, has attracted considerable attention for its potential to enhance disease and cancer therapy efficacy through nanotechnology-based integration and delivery. This study draws on literature from the Web of Science Core Collection database to assess the current status and development trajectories within quercetin nanotechnology research. Employing the Bibliometrix toolkit in R (via Biblioshiny ) alongside VOSviewer for bibliometric analysis, this research systematically examines annual publication patterns, influential works, and thematic evolution in quercetin nanotechnology from 2009 to December 2024. The comprehensive analysis identified 218 relevant publications, comprising 122 articles and 96 reviews. Through an in-depth evaluation of highly-cited publications, keyword co-occurrence density, and thematic progression, this study reveals a shift in research focus, evolving from initial efforts to enhance quercetin bioavailability via nanotechnology up to advanced investigations targeting oxidative stress, inflammation, cancer, and chronic disease management. Additionally, the analysis identifies emerging trends, including the development of novel quercetin-based nano-formulations for a targeted drug delivery and exploration of synergistic effects with other therapeutic agents. This bibliometric study serves as a valuable resource, offering researchers a comprehensive overview of the current research landscape and guiding future investigations through the unsolved research gaps into the application of quercetin nanotechnology, particularly in diseases and cancer therapy.