Beetroot (Beta vulgaris) - Fortified Yogurt as a Natural Source of Levodopa Enhances in Rotenone – induced Parkinson's Disease in Mice

Background: Parkinson’s disease (PD) is a common neurodegenerative disorder; however there is still a lacks of effective and safe treatments for it. Beetroot is a unique plant containing rich in betalains. It has shown protecting dopamine cells effects. Aim: To evaluate the effect of beetroot fortified yogurt on PD symptoms in mice compare to levodopa drug. Methods: PD was induced in adult male Swiss albino mice by rotenone through 9 subcutaneous injections 1.5 mg/kg; 3 times / week. Locomotor activity was assessed by behavioral tests, and some biochemical analyses were conducted. Results: Beetroot fortified yogurt improved locomotor activity and reduced PD markers such as, oxidative stress biomarkers, Neurotransmitters, Apoptotic Indices, Inflammatory Indices, liver and kidney functions and Constipation. Conclusions: Red beet fortified yogurt and inhibited the development of PD in mice better than levodopa drug, which may be partly responsible for decreased oxidative damage and enhances dopamine production in brain.