Seven-gene biomarkers reveal prognostic and immune signatures in lung adenocarcinoma

Background Lung adenocarcinoma (LUAD) has high morbidity and mortality, with its mechanisms and treatment still under investigation. Methods Differentially expressed genes (DEGs) between LUAD and normal tissues were identified from three GEO datasets. Gene enrichment and protein-protein interaction (PPI) analyses were performed, with hub genes identified. Results Sixty-eight overlapping DEGs were found. The PPI network highlighted nine hub genes, and survival analysis linked seven of them (AGER, CAV1, EDNRB, ROBO4, EMCN, TEK, PTPRB) to LUAD prognosis. Clinical and immune analyses demonstrated these genes' significant roles in LUAD progression. ROC and PCA confirmed their diagnostic potential. Conclusions These seven genes, downregulated in LUAD, could serve as biomarkers and therapeutic targets, requiring further research.