Identification of the factors associated with intraperitoneal pressure in children with peritoneal dialysis

Background : The increased Intraperitoneal Pressure（IPP）is considered the predisposing factor for complications of PD in children, however the research on IPP on peritoneal dialysis patients in China remains limited, particularly in children.This study aim to further determine the relevant factors for increased IPP in children undergoing peritoneal dialysis. Methods: We conducted a retrospective observational study of children under 18 years of age with peritoneal dialysis at Children’s Hospital of Fudan University between May 2019 and June 2024.Patient characteristics,IPV,IPPs were collected.IPPs were measured continuously at different filling volumes.the Univariate analysis and multivariate linear regression were used to assess the risk factor of IPP. Results: A total of 101 cases of children were collected,of which 53(52.5%) cases was male,median age of 6.5(4.02,11)years.at the IPV were 600ml,800ml,1000ml,1200ml and 1400ml,the mean±SD of IPP was 9.82±2.05cmH ₂ O,8.76±2.02cmH ₂ O,10.86±2.16cmH ₂ O,11.95±2.32cmH ₂ O,12.98±2.33cmH ₂ O.The duration time of PD (B= 0.02, p=0.03),BSA (B=-1.64, p= 0.035),and BMI(B=0.53, p<0.001) are significant factors associated with increased IPP while body weight was significant only in the univariate analysis, this association was no significant after multivariate adjustment. Conclusions: Our study demonstrate the IPP was influenced by multiple factors in PD children.Notably, BMI, BSA, and PD duration were the main independent factors,these finding have significant implication in clinical practice,IPP monitoring as a simple and non-invasive measurement technique,it provides critical insights for clinicians to optimize dialysis prescriptions, thereby refining therapeutic regimens and management strategies for pediatric PD patients.