Invasive pneumococcal disease in a Level 4 teaching hospital in Dublin in period 2012 – 2023

Streptococcus pneumoniae is a major pathogen, causing invasive infection in children and adults. The current study retrospectively evaluated IPD in adults in a level 4 teaching hospital in 12-year period. Data on invasive SPN was extracted from Microbiology laboratory system and clinical data from the Patient Centre Information System. All patient data were anonymised at the time of collection. Total number of IPD cases in studied period was 210. Mean age of the patients was 57.9 years, and male: female ratio 1.7. All-cause mortality at 12 months was 50 (23.8%). The susceptibility and serotypes of the organism were assessed. An associated cost of the disease was calculated, and it showed that 7 034 556 € was the total inpatient cost of the disease. Our data showed, that IPD is a severe disease with significant morbidity, mortality and associated cost. Financial calculation showed significant amount of money, considering the fact, that the disease is vaccine preventable. Irish data suggests, that vaccine uptake in adults is suboptimal nationally, ranging between 27% and 36%. There is a need to increase vaccine uptake in adults.