Transcriptional expression of CAV1 in total and adipose tissue exosomes are associated with poor-quality diet, adiponectinemia, alcoholism, diastolic blood pressure, and cardiovascular risk by Framingham Colombia scale in adults from Cartagena

Overweight and obesity has pandemic dimensions, and are the main risk factors for the increased prevalence of type 2 diabetes, metabolic syndrome, and various cancers globally. It is conceived that the expression of CAV1 in the adipose tissue would be associated with the development of adipogenesis and obesity. However, to date there is no clarity regarding the differences in transcriptional expression of CAV1 in adipose tissue in states of normal-weight, overweight, and obesity, much less is known whether the adipose tissue would promote adipogenesis in distant organs via exosomal caveolin-1, and in turn, overweight and obesity, and whether such differences in CAV1 expression could be related to environmental risk factors for the development and maintenance of obesity. The main objective of this study was to evaluate associations between CAV1 expression in total and adipose tissue exosomes presents in peripheral blood of adults from Cartagena in normal-weight, overweight, obesity, severity of obesity, and comorbidities with dietary quality, dietary patterns, smoking, alcoholism, physical activity, blood biochemistry, anthropometric cardiovascular risk (CVR), and CVR by International and Colombia Framingham scales. We found that CAV1 is overexpressed in total exosomes from obeses, type 2 diabetics, and hypertensives adults, and such increases were associated with hyperadiponectinemia, poor-dietary quality, and reductions in diastolic blood pressure. Furthermore, CAV1 is overexpressed in adipose tissue exosomes from overweight, obeses, type 2 diabetics, and hypertensives adults, and such increases was associated with poor-dietary quality, reduced CVR by Colombia Framingham scale, and inversely with alcohol consumption and physical activity.