The prognostic value of preoperative albumin-hemoglobin grade in patients with hypopharyngeal cancer

Background and objectives The prognostic markers for evaluating survival rates in patients with hypopharyngeal carcinoma remain controversial. This study aimed to evaluate the prognostic significance of preoperative albumin-hemoglobin grading in hypopharyngeal carcinoma patients. Methods A retrospective analysis was conducted on 214 postoperative hypopharyngeal carcinoma patients. Receiver operating characteristic Receiver Operating Characteristic Receiver Operating Characteristic curve analysis was performed to compare the predictive capacity of prognostic markers and determine optimal cut-off values. Kaplan-Meier survival analysis with log-rank testing and multivariate Cox proportional hazards regression models were utilized to assess associations between prognostic markers and overall survival or cancer-specific survival. Results Serum albumin and hemoglobin were identified as optimal prognostic factors. albumin<41.65 g/L or hemoglobin<136.5 g/L significantly correlated with decreased overall survival(P<0.05). The 5-year overall survival rates were 62.8% (grade A), 48.8% (grade B), and 18.4% (grade C) (P=0.000), while cancer-specific survival rates were 66.0%, 52.4%, and 23.7%, respectively (P=0.000). Multivariate analysis demonstrated that the albumin-hemoglobin grading system served as an independent prognostic factor for both overall survival and cancer-specific survival. Conclusion The albumin-hemoglobin grading system is an independent predictor of poor postoperative survival in hypopharyngeal carcinoma patients.This study aimed to investigate the prognostic value of preoperative ALB-HB grade in patients with HPC.