Effect of Natural Super Disintegrant in the Formulation of Mouth Dissolving Tablets (MDTs) of Aspirin

Background: The formulation of MDTs is preferred for the patients due to their ease of use and quick disintegration profile. Therefore, the MDTs have become more popular as a patient-centred dosage form. An effective formulation of aspirin into MDTs utilizing natural super disintegrants can be extensively used as an analgesic and anti-inflammatory. Objective: This present work focuses on the formulation and evaluation of MDTs of Aspirin. Methods: The formulation uses natural super disintegrants from microbiological or botanical sources. This formulation was optimized using the software JMP, which has enormous features in optimizing the design by using the classic model to design experiments, followed by analyzing the fit model curve. The predictions were fully refurbished and redefined in a well-versed manner. Moreover, tablet disintegration and dissolving kinetics were improved by using a variety of plant-based super disintegrants such as gelatin and chitosan and various natural super disintegrants. The direct compression method was employed to prepare the optimized formulation. Then, the formulation was evaluated by drug release profile, disintegration time, friability, and tablet hardness. Results: MDTs were formulated and evaluated for their physicochemical and drug release profiles. The A8 formulation code meets the standards for pharmaceutical preparation and is suitable for use. The drug release percentage was, 94.8% indicating its suitable effectiveness. Conclusion: Compatibility problems and regulatory considerations are among the challenges faced when formulating MDTs. Ultimately, this study, the potential impact of natural super disintegrants in the development of MDTs of aspirin in pharmaceutical practice.