Protective Effects of Date Syrup And Green Tea Against Atrazine-Induced Hepatic And Reproductive Toxicity In Male Albino Wistar Rats

Background : Drug-induced hepatotoxicity and reproductive dysfunction remain significant clinical challenges, necessitating novel protective agents. Existing therapies often fail to concurrently address liver and gonadal damage, highlighting the need for multifunctional interventions. Aim : This study evaluated the hepatoprotective and fertility-preserving effects of a novel compound in a atrazine-induced rodent model, comparing its efficacy against standard and experimental treatments Study design: Experimental study. Place and Duration of Study: Department of Pharmacy Technician, Federal College of Health Technology Ilese-Ijebu Ogun State Nigeria, between August 2024 and November 2024.. Methodology : Forty-eight male Wistar rats were divided into six groups (n=5): Group I (normal control), Group II (positive control, toxin-exposed), and Groups III-VI (toxin + test compounds). After 28 days, serum AST, ALT, GGT, ALP, 5'NT, albumin, total protein, sperm parameters, and hormonal levels were analyzed using standard procedures. Statistical significance was assessed via ANOVA and Tukey’s post-hoc tests (p < 0.05). Results : Group II exhibited severe hepatotoxicity (AST: 81.56±1.245 IU/L; ALT: 57.32±0.412 IU/L) and reproductive impairment (sperm count: 22.6±1.8×10⁶/mL; testosterone: 3.45±0.18 ng/mL). Group VI demonstrated near-normal liver enzymes (AST: 70.62±0.495; ALT: 38.94±3.872), preserved albumin (4.660±0.0512 g/dL), and improved sperm count (42.6±2.0×10⁶/mL) versus Group II (p < 0.0001). Conclusion : The novel compound in Group VI significantly mitigated both hepatic and reproductive toxicity, outperforming other interventions. These findings suggest a dual-organ protective mechanism, potentially mediated through antioxidant or anti-inflammatory pathways. Future studies should isolate the active constituents of Group VI and validate results in higher mammalian models. Clinical trials are warranted to assess translational potential in chemotherapy-associated toxicity.