Multi-Perspective Machine Learning MPML: A High-Performance and Interpretable Ensemble Method for Heart Disease Prediction

Machine Learning (ML) has demonstrated strong predictive capabilities in healthcare, often surpassing human performance in pattern recognition and decision-making. However, many high-performing models lack interpretability, which is critical in clinical settings where understanding and trusting predictions is essential. To address this, we introduce Multi-Perspective Machine Learning (MPML)—an ensemble approach that integrates multiple complementary techniques to form a high-performing, interpretable model. MPML organizes features into meaningful subsets, or perspectives, enabling both global and instance-level interpretability. Unlike traditional ensemble methods such as Bagging, Boosting, and Random Forest, MPML delivers significantly higher-quality predictions across all evaluation metrics while maintaining a transparent structure. Applied to a heart disease dataset, MPML not only improves predictive accuracy but also provides detailed, accessible explanations for individual patient outcomes, advancing the potential for practical and ethical deployment of ML in healthcare.