Synthesis and characterization of nanoporous TiO2/SBA-16-NH2: Its efficiency as drug delivery system

In this study, the TiO ₂ /SBA-16-NH ₂ was synthesized by the green method from the reed plant stem. To characteristics of this nanocomposite, several techniques such as XRF, XRD, SEM, TEM, TGA, and BET were applied. The response surface methodology (RSM) with central composite design (CCD) was used to inspect the loading and release of the carbamazepine drug by TiO ₂ /SBA-16-NH ₂ nanocomposite. Also, main and interactive parameters such as initial concentration of the drug, nanocomposite dose, pH, contact time, and temperature were studied to obtain the optimum conditions for this novel nanocarrier. Drug release in three different environments at 37 ℃ including aqueous medium with pH = 6.8, acidic with pH = 4.8, and alkaline with pH = 7.4 at times of 1, 2, 3, 4, 12, 24, 48, and 72 hours was studied. The Langmuir, Friendlich, and Temkin isotherms were also considered and the results show the Langmuir model (R ² =0.9976) is more suitable than the other models. The thermodynamic study showed that loading of the drug on TiO ₂ /SBA-16-NH ₂ nanocomposite is an exothermic and spontaneous process at low temperatures. Also, Kinetics shows that the loading and release kinetics follow the first-order equation (R ² =0.9974).