The acidity of the tumor microenvironment enhances the immunosuppressive role of MDSCs via activating ASICs
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A common feature of solid tumors is tumor microenvironment acidification. The acidification triggers immunosuppressive mechanisms that enhance cancer cell survival and growth and facilitate tumor progression. MDSCs (Myeloid-derived suppressor cells) are activated by these mechanisms. Acid-sensing ion channels (ASICs) mainly help to acidify the microenvironment. It's unclear how acidification triggers the activation of MDSCs through ASICs. Research into the mechanisms has demonstrated that MDSCs produce numerous immunosuppressive substances and cytokines through the use of ASICs multiple subunits. The NF-κB and STAT signaling pathways are the main activators of these subunits. Findings of this study suggest that ASICs are implicated in the effect of acidosis on the function of MDSCs in TME.
