Impact of Early Initiation of Antimicrobials on Acute Kidney Injury Due to Sepsis

Background: This study evaluates the effect of early antimicrobial administration on the incidence and severity of acute kidney injury (AKI) in septic patients. Through a prospective analysis, we collected data from patients diagnosed with sepsis. Findings suggest that prompt initiation of appropriate antimicrobials significantly reduces the risk of AKI and improves patient outcomes. Objective: The objective is to assess the impact of the timing of antimicrobial therapy on kidney function recovery in patients with sepsis-induced acute kidney injury. Patients and methods: A 297 patients admitted to intensive care unit Suez Canal University Hospital with sepsis and acute kidney injury are included. Results: Patients receiving their first antibiotic dose within 4 hours (73.1%) and between 4-8 hours (87.8%) showed significantly improved kidney function without the need for hemodialysis, compared to those with delays > 8 hours (18.29%; p<0.001). Approximately 65% presented with Stage III AKI. Conclusion : These findings highlighted the critical importance of timely antimicrobial intervention to enhance renal recovery and improve overall patient outcomes in sepsis-induced AKI.".