Comparing Efficacy and Safety of Mechanical Thrombectomy in Vertebrobasilar Tandem Occlusion Versus Isolated Basilar Artery Occlusion Stroke: A Systematic Review and Meta-Analysis

Background Basilar artery occlusion (BAO) is a rare stroke type, with subtypes like vertebrobasilar tandem occlusion (VBTO), complicating treatment. Mechanical thrombectomy (MT) is increasingly used, but evidence on its safety and effectiveness in VBTO compared to non-VBTO or isolated BAO (iBAO) remains limited. Methods PubMed, Cochrane Central and ScienceDirect were searched till May 2025. The risk ratios (RR) were pooled along with 95% Confidence intervals (CI) under the random effects model using Review Manager. The Newcastle Ottawa Scale and GRADE assessment were used to assess the quality of studies and certainty of evidence. Publication bias was assessed using funnel plots and Egger’s regression test. Results Nine studies, pooling a total of 737 patients, were included in this analysis. MT showed no significant difference in functional independence in the VBTO group compared to the iBAO group (RR = 1.25; 95%CI:[0.73, 2.12]; p = 0.42). The successful recanalization was also comparable between the VBTO and iBAO arms when MT was performed (RR = 0.96; 95%CI:[0.81, 1.13]; p = 0.60). The risk of symptomatic intracerebral hemorrhage (sICH) was significantly increased when MT was performed in the VBTO arm compared to the iBAO group (RR = 2.20; 95%CI:[1.09, 4.46]; p = 0.03). The mortality rates were also comparable between the two groups (RR = 1.28; 95%CI:[0.78, 2.10]; p = 0.33). Also, in the VBTO patients, the successful recanalization rate showed no significant difference between the clean and dirty road techniques (RR = 1.04; 95%CI:[0.90, 1.20]; p = 0.63). Conclusion When MT was performed on VBTO and iBAO patients, the efficacy endpoints—such as functional independence and successful recanalization—and the safety endpoint of mortality were comparable. However, the risk of sICH was higher in the VBTO group.