The experience of recalled trauma during psychedelic experiences and perceived links to subsequent extended difficulties: A mixed-methods study

This mixed-methods study investigated the relationship between recalled childhood trauma during psychedelic experiences and subsequent extended psychological difficulties. While psychedelics can facilitate emotional processing of autobiographical material, a minority experience adverse effects or re-traumatization when trauma resurfaces. Phase 1 surveyed 608 individuals who experienced post-psychedelic difficulties lasting beyond acute effects. Those linking difficulties to early trauma (41.8%) were significantly older, more often female, were more likely to report a prior mental-illness diagnosis, and were more likely to use psychedelics in guided settings compared to those without trauma links. They also reported significantly more emotional difficulties but fewer perceptual difficulties after the experience. Phase 2 involved semi-structured interviews with 18 purposively selected participants. Reflexive thematic analysis identified four themes: direct trauma re-experiencing (39% of participants, including some with no prior memory of events), symbolic/somatic re-embodiment (22%), fragmentation and confusion (50%), and varied post-experience trajectories. Outcomes ranged from predominantly positive integration (50%) to mixed effects (28%) to re-traumatization (22%). The study highlights uncertainty around memory veridicality as a source of ongoing distress for some participants. Findings emphasize the critical need for trauma-informed approaches to psychedelic use, stressing appropriate preparation, supportive settings, and robust integration support to maximize therapeutic potential while preventing re-traumatization.