Burden and Trends of Diet-Related Colorectal Cancer in Global, East Mediterranean, and China ：Systematic Analysis Based on Global Burden of Disease Study 1990-2021 with Projections to 2050

Colorectal cancer (CRC) is the third most common cancer and the second most frequent cause of cancer death worldwideThis study aimed to systematically analyze Burden and trends of the diet-related CRC in global,the Eastern Mediterranean Region (EMR), and China from 1990 to 2021. so as to provide a basis for region-specific prevention and control strategies.From 1990 to 2021, dietary factors remained the primary preventable cause of CRC globally. While the number of diet-related CRC deaths and DALYs increased significantly in global, the age-standardized rates declined. China showed a consistent trend with the global. In contrast,EMR exhibited an opposite trend to the global CRC burden: the number of deaths increased by 171.37% and DALYs by 169.53%, with rising age-standardized rates (EAPC = 0.46% for mortality and 0.30% for DALYs).Dietary factors remain the primary preventable contributor to the global burden of CRC, with an overall increasing trend accompanied by significant regional and population heterogeneities. Developing targeted strategies tailored to regional dietary patterns, gender, and age-specific characteristics is crucial for effectively alleviating the burden of colorectal cancer.