A Crowdsourced Megastudy of 12 Digital Single-Session Interventions for Depression in American Adults

  1. Benjamin Kaveladze
  2. Jan Voelkel
  3. Michael Stagnaro
  4. Mingjing Huang
  5. Amanda Smock
  6. Erin Sullivan
  7. Yao Xu
  8. Madison McCall
  9. Juan Pablo Zapata
  10. Syed Ishtiaque
  11. Ananya Bhattacharjee
  12. Iva Georgieva
  13. Rosa Hernandez-Ramos
  14. Kenneth Huber
  15. Julia Jennings
  16. Arianna Kirk
  17. Rachel Kornfield
  18. Robert Knowles
  19. Monika Lind
  20. Michelle Liu
  21. Michael Liut
  22. Alex Mariakakis
  23. Ali Mattu
  24. Adam McGuire
  25. Jonah Meyerhoff
  26. Alissa Mrazek
  27. Michael Mrazek
  28. David Mohr
  29. Robert Morris
  30. Christopher Mosunic
  31. Hana Nip
  32. Allen Olson-Urtecho
  33. Jessa Podell
  34. Dustyn Ransom
  35. Shireen Rizvi
  36. Matthew Southward
  37. Sarah Elizabeth Stoeckl
  38. Madison Taylor
  39. Amy Texter
  40. Angelique Trotter
  41. Calvin Tower
  42. Joseph Williams
  43. Elijah Woodson
  44. Katherine Wislocki
  45. John Protzko
  46. Lorenzo Lorenzo-Luaces
  47. Stephen Schueller
  48. Matthew Nock
  49. Jessica Schleider
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Abstract

Digital self-guided single-session interventions (SSIs) provide a structured psychological intervention within one interaction. We crowdsourced 66 diverse 10-minute SSIs for depression and selected 11 for testing in a pre-registered “megastudy” (ClinicalTrials.gov ID: NCT06856668). American adults (N = 7,505) experiencing elevated depressive symptoms were recruited online and randomly assigned to one of the 11 crowdsourced SSIs, a previously-validated active comparison SSI, or a control without intervention content. Nearly all SSIs boosted agency and hope for improvement immediately after completion (ds ≤ 0.37). However, only two significantly reduced depression at four-week follow-up (ds = 0.14 and 0.15). Unexpectedly, some SSIs may have decreased readiness to change at four weeks (ds ≤ 0.14). The most successful SSIs provided focused, engaging, and actionable guidance on a skill that directly addressed users’ struggles. Future work should aim to leverage SSIs’ short-term gains to promote longer-term behavior change or service engagement.

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  1. Version published to 10.21203/rs.3.rs-7236847/v1 on Research Square