Enhancing Dentin Bond Strength with Resveratrol: Effects Across Time Intervals

The longevity of adhesive restorations in endodontically treated teeth is often compromised by degradation of the resin-dentin interface due to hydrolysis and enzymatic breakdown of collagen. Resveratrol, a natural polyphenol, has shown potential in stabilizing collagen and promoting dentin biomodification. This study evaluated the effect of incorporating resveratrol into a dentin bonding agent on the push-out bond strength of glass fibre posts to root dentin, assessed immediately and after six months. Eighty single-rooted human premolars were sectioned to obtain 1 mm-thick middle-third dentin discs. Samples were divided into two groups: control (plain adhesive) and experimental (adhesive with 1 mg/mL resveratrol). glass fibre posts were bonded, and push-out bond strength was measured at baseline and after six months of storage in collagenase type I solution. FTIR spectroscopy was conducted to analyze chemical interactions. Results showed no significant difference in immediate push-out bond strength between groups. However, after six months, the resveratrol group retained bond strength significantly better. FTIR analysis revealed increased O–H stretching and intensified amide I and PO₄³⁻ bands in resveratrol-treated samples, indicating enhanced hydrogen bonding, reduced collagen degradation, and potential remineralization. Resveratrol improves long-term bond durability, supporting its use as a dentin biomodifier in adhesive systems.