Prognostic Value of Left Ventricular Lead Impedance in Cardiac Resynchronization Therapy

Background: Cardiac resynchronization therapy (CRT) improves outcomes in heart failure patients, but response remains variable. New predictive tools are needed. Methods: A retrospective analysis of CRT patients was conducted using a multivariate logistic regression model. Predictors included left ventricular impedance change, BMI, age, and sex. EF improvement ≥ 10% was the outcome of interest. Results: Male sex (OR = 3.22), early impedance increase (OR = 2.82), and late impedance increase (OR = 2.01) were significantly associated with EF improvement. The model achieved an AUC of 0.77. Conclusion: LV lead impedance trends, combined with clinical variables, may support early prediction of CRT response and aid in patient stratification.