Dose distribution with Monte Carlo simulation, imaging, and pharmacokinetic studies of radiopharmaceutical for colon cancer

Colon cancer is a widespread form of cancer worldwide. According to FDA-approved radio imaging, nanosystems are the primary carriers of radionuclides. This study examines colon tissue's specific mass attenuation coefficient and its significance in medical imaging and radiation therapy for various conditions, including colorectal cancer.Understanding the mass attenuation coefficient of colon tissue can help optimize nuclear imaging techniques like SPECT/CT and PET/CT and minimize damage to healthy tissue surrounding the affected area during radiation therapy. Studying colon tissue's specific mass attenuation coefficient and its variations in different pathological conditions can significantly contribute to developing more sensitive and targeted medical imaging and treatment strategies for colorectal cancer and other colon-related diseases.It was determined that the Tc-99m-IMT-NSLC formulation was retained in the colon cancer area in higher amounts than the Tc-99m-IMT solution. In addition, using Monte Carlo simulation, MATLAB and WinXCOM calculated how photons are attenuated by the small intestine tissue, which is essential in nuclear medicine, medical imaging, and radiation dosimetry.This targeted research can significantly contribute to an advanced understanding of the unique characteristics and applications of the mass attenuation coefficient in the context of colon tissue, fostering advancements in medical science and technology.