One-year creatinine predicts long-term graft survival in pediatric kidney transplant recipients

Background: In pediatric kidney transplant recipients long-term graft survival remains variable necessitating methods to predict the timing of graft failure. Studies in adults have identified post-transplant serum creatinine (sCr) as a biomarker for graft survival. Our goal was to investigate the predictive value of one-year sCr levels on long-term graft survival in pediatric kidney recipients. Methods: We performed a retrospective cohort study of Organ Procurement and Transplantation Network data. We identified 8,733 pediatric kidney transplant recipients between 2008 and 2021 with reported one-year sCr levels. Patients were grouped by sCr level: ≤1.0, 1.0-1.5, 1.5-2.0, and ³2.0 mg/dL. We analyzed long-term graft survival with a Kaplan-Meier curve and a multivariable Cox-proportional hazard model. We developed a predictive score derived from a sCr based model and an estimated glomerular filtration rate (eGFR) based model and compared them using DeLong’s test. Results: Mean one-year sCr was 0.88 mg/dL, and higher one-year sCr predicted long-term graft failure (sCr 1.0 to 1.5 adjusted hazard ratio (aHR) 1.73, sCr 1.5 to 2.0 aHR 2.64, sCr ³2.0 aHR 6.92, p<0.001 for all). The mean one-year eGFR was 71.66 mL/min/1.73m². Compared to patients with eGFR ≥90, risk of graft failure increased stepwise with lower eGFR (eGFR 60-90 aHR 1.27, eGFR 45-60 aHR 1.70, eGFR 30-45 aHR 2.62, eGFR <30 aHR 9.05, p<0.004 for all). Predictive ability was similar between eGFR and sCr-based models (p=0.116). Conclusions: Utilizing one-year sCr may allow for early identification of patients at risk of graft failure for careful surveillance and prognostication for patient expectations.