Allogeneic hematopoietic stem cell transplantation combined with low-dose Linperlisib maintenance treatment for primary refractory vascular immunoblastic T-cell lymphoma: a case report

Objective: This research focuses on examining the management of primary refractory vascular immunoblastic T-cell lymphoma. Methods : We present a case of this lymphoma type and conduct a review of related literature. Results : A male patient in his middle age was diagnosed with vascular immunoblastic T-cell lymphoma classified as Ann Arbor stage IVB, with an International Prognostic Index (IPI) score of 3. The BV+CHP chemotherapy administered at this advanced stage proved ineffective, resulting in disease progression. Nevertheless, complete remission occurred after performing allogeneic hematopoietic stem cell transplantation in conjunction with low-dose Linperlisib maintenance therapy. Conclusion : The combination of allogeneic hematopoietic stem cell transplantation with low-dose Linperlisib maintenance therapy has demonstrated efficacy for certain instances of primary refractory recurrent vascular immunoblastic T-cell lymphoma. This approach may serve as an alternative for patients unable to tolerate intensive chemotherapy for refractory recurrent T-cell lymphoma. Due to the limited number of cases, further clinical data is necessary to clarify its effectiveness.