Pulsed Spectral Resonance Therapy: Nonthermal, Contactless Disintegration of Malignant Tumors via Modal Collapse

A paradigm shift in cancer therapy is proposed, wherein tumor ablation is reconceptualized not as a problem of energy deposition, but of vibrational topology. A nonthermal, contactless strategy is introduced, based on phase-locked external excitation precisely tuned to the eigenfrequencies of malignant tissues. This targeted resonance induces localized strain accumulation along spectrally isolated vibrational modes, culminating in mechanical collapse confined strictly to pathological structures. Thermal diffusion, ionizing radiation, and cytotoxic agents are entirely circumvented. In contrast to conventional ablation modalities—thermal, cavitation-based, or chemical—the method leverages intrinsic spectral, elastic, and geometric asymmetries of tumors to enable precision targeting through spectral detuning. Healthy stroma remains unaffected. Finite-element simulations and multilayer phantom experiments demonstrate robust spectral confinement, mechanical quality factors exceeding 30, and collapse events occurring safely below conventional thermal thresholds. Aggressive malignancies such as pancreatic and triple-negative breast cancers, typically refractory to standard interventions, exhibit distinct modal fingerprints under this framework. This enables high-specificity ablation, even within deeply infiltrative or surgically inaccessible tissues. By reframing oncological intervention as a resonance driven topological phenomenon, this work lays the mechanistic and translational foundation for a new class of therapies—spectral oncology—integrating vibrational physics, biomedical engineering, and image-guided precision. Clinical deployment is envisioned in the form of frequency-tunable ablation platforms, adaptable to tumor type, anatomical location, and individualized spectral profiles.