In-Vitro Antibacterial Activity of Retinoic Acid (Vitamin A) Against Antibiotic-Resistant Bacteria

Read the full article See related articles

Discuss this preprint

Start a discussion What are Sciety discussions?

Listed in

This article is not in any list yet, why not save it to one of your lists.
Log in to save this article

Abstract

Antibiotic resistance poses a grave threat to global public health, necessitating the search for alternative antibacterial agents. This study investigates the in-vitro antibacterial efficacy of retinoic acid (Vitamin A) against antibiotic-resistant strains of gram-positive and gram-negative bacteria. Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes , along with gram-negative bacteria including Escherichia coli and Klebsiella pneumoniae , were subjected to treatments with retinoic acid of varying concentrations. The results demonstrate a direct inhibitory effect of retinoic acid on the growth of both antibiotic-resistant and susceptible strains of Staphylococcus aureus and Streptococcus pyogenes . While Escherichia coli exhibited sensitivity to retinoic acid, Klebsiella pneumoniae showed only a limited susceptibility. Statistical analysis confirmed the significance of these findings. The study underscores retinoic acid's potential as a novel antibacterial treatment, particularly against antibiotic-resistant infections. Further research into retinoic acid's mechanisms of action and its clinical applications may offer new avenues for combating antibiotic resistance.

Article activity feed