In-Vitro Antibacterial Activity of Retinoic Acid (Vitamin A) Against Antibiotic-Resistant Bacteria
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Antibiotic resistance poses a grave threat to global public health, necessitating the search for alternative antibacterial agents. This study investigates the in-vitro antibacterial efficacy of retinoic acid (Vitamin A) against antibiotic-resistant strains of gram-positive and gram-negative bacteria. Gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes , along with gram-negative bacteria including Escherichia coli and Klebsiella pneumoniae , were subjected to treatments with retinoic acid of varying concentrations. The results demonstrate a direct inhibitory effect of retinoic acid on the growth of both antibiotic-resistant and susceptible strains of Staphylococcus aureus and Streptococcus pyogenes . While Escherichia coli exhibited sensitivity to retinoic acid, Klebsiella pneumoniae showed only a limited susceptibility. Statistical analysis confirmed the significance of these findings. The study underscores retinoic acid's potential as a novel antibacterial treatment, particularly against antibiotic-resistant infections. Further research into retinoic acid's mechanisms of action and its clinical applications may offer new avenues for combating antibiotic resistance.