Radiotherapy for benign conditions: management of persistent lymphorrea

Background: Lymphorrhea is a complication that can arise after vascular, abdominal or pelvic interventions and is associated with significant morbidity. While conservative management is typically effective, some cases remain refractory. Methods: This retrospective cross-sectional study analyzed 43 patients with persistent inguinal lymphorrhea treated at a tertiary hospital between 2008 and 2018. All patients received external beam radiotherapy (EBRT) using 3D conformal techniques with photons (6–18 MV). The delivered dose was 7.5 Gy in five 1,5 Gy/fractions. Results: Complete closure of the lymphatic fistula was achieved in all patients. Three required reirradiation with the same schedule to reach complete resolution. No acute or late toxicity was observed in any case. Conclusions: Low-dose EBRT is a safe and effective treatment option for persistent lymphorrhea refractory to conservative measures. Its anti-inflammatory and fibrosing effects support its therapeutic use in benign lymphatic complications. Trial Registration Not applicable.