Moderate-Intensity Continuous Training Is a Safe Exercise Intervention for Patients with Underexcretion Hyperuricemia

Background/Objectives Uric acid excretion insufficiency is a major etiology of Hyperuricemia (HUA). While exercise intervention serves as a non-pharmacological uric acid-lowering strategy, acute exercise may cause transient serum uric acid (SUA) elevation, posing risks to HUA patients. This study investigated the acute effects of moderate-intensity continuous training (MICT) on Underexcretion Hyperuricemia and explore the safety of MICT for these patients. Methods The study used a self-controlled pre-post design. Prior to the experiment, 24-hour urine collection and fasting venous blood sampling were conducted. Patients were classified based on 24-hour urinary uric acid (UUA) excretion and fractional excretion of urate (FE _UA ). A total of 18 patients with Underexcretion Hyperuricemia were finally included in the acute MICT intervention. Blood/urine samples were collected pre-intervention, post-intervention, and 30 min post-intervention. Results No significant changes were observed in SUA and UUA before and after the acute exercise intervention ( P  > 0.05). Blood lactate immediately after exercise intervention was significantly higher than that before intervention ( P  < 0.01). Serum creatinine (SCr) immediately after exercise and 30 minutes after exercise was significantly higher than that before exercise ( P  < 0.05). FE _UA ( P  < 0.001), UUA/UCr ( P  < 0.01), and Simkin index ( P  < 0.001) at 30 minutes after exercise intervention were significantly higher than those before intervention. Conclusions MICT did not elevate SUA in Underexcretion Hyperuricemia patients but enhanced uric acid excretion capacity, confirming its safety as an exercise intervention modality.