KIF20A- A New Discovery in Tumor Therapy

Background KIF20A is a cell cycle-related protein playing a crucial role in cell mitosis and participating in important steps such as chromosome segregation, spindle assembly, and cytoplasmic division. Methods Based on bioinformatics databases, KIF20A expression levels and their relationship with immune cell infiltration (ICI) were examined by means of TIMER and TCGA, tumor prognosis was assessed through one-way COX regression and Kaplan-Meier (KM) analyses, while genetic mutations were analyzed using cBioPortal. The R programming language was adopted for immune checkpoint (ICP) and pathway enrichment analyses. Results KIF20A exhibits significant expression elevation in the majority of cancers, and KIF20A protein is also highly expressed. Tumors demonstrating high KIF20A expression are associated with worse prognostic outcomes. Elevated KIF20A expression is positively linked to ICI, tumor mutational burden (TMB), and ICPs across most tumors. Amplification is the most frequent genetic alteration that the KIF20A gene undergoes. This extensive pan-cancer analysis provides enhanced understanding of KIF20A's role in tumorigenesis and metastasis. Conclusions KIF20A as a new target gene opens a new path for tumor treatment and diagnosis, and inhibiting this gene has the potential to improve tumor prognosis and prevent tumorigenesis.