Olink proteomics analysis of scalp psoriasis reveals a cytokine storm inflammatory mainly related to bacterial-derived antigens
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Background Scalp psoriasis (SP) is a common, chronic, and relapsing inflammatory skin disease whose pathogenesis is still not completely clear. Few proteomic studies of SP are available. Methods We used Olink high-throughput proteomics to identify 92 inflammatory markers in lesional and no-lesional skin of adult patients with SP. Results We identified 34 DEPs in the lesional scalp compared to no-lesional skin. SP lesional skin demonstrated a wide range of immune and chemokine molecules involved in the inflammatory response, focusing on Th1, IL-12/IL-23, and Th17 relevant immune signalling pathway. The lesional skin of SP also shows a dysregulation of symbiosis, encompassing mutualism and response to biotic stimuli concerned with bacteria. Conclusions Our findings suggested a cytokine storm inflammatory response in SP lesions, which is mainly related to bacterial-derived antigens.
