A Study of the Efficacy of Nasal High Flow in Maintaining Oxygenation in Patients Undergoing Dental Treatment under Procedural Sedation

Introduction Procedural sedation during dental treatment has been reported to have a high incidence of respiratory depression. Nasal high flow (NHF) therapy uses a mild positive pressure load that improves carbon dioxide washout and reduces rebreathing to improve respiratory function and therefore is widely used to prevent hypoxemia and hypercapnia. We will investigate the efficacy of respiratory support with NHF during dental treatment under procedural sedation. Methods/design In a multicenter randomized controlled study of two groups, the NHF group and low flow oxygen group, for adult patients who underwent dental treatment under procedural sedation. For sedation, midazolam plus propofol were used according to the guidelines to obtain moderate sedation level. The primary endpoint is the incidence of hypoxemia, defined as SpO₂ ≤ 90% during intravenous anesthesia. As a secondary evaluation item, the percutaneous CO ₂ concentration is evaluated to examine whether it is effective in preventing hypercapnia. Furthermore, we will evaluate Sedative and analgesic doses, and examine whether the use of equipment is effective in preventing the occurrence of hypercapnia and hypoxemia. Discussion The purpose of this study was to obtain evidence for the utility of NHF as respiratory support for dental treatment under procedural sedation, assessed by determining if the incidence rates of hypercapnia and hypoxemia can be decreased by NHF. Trial registration The study was registered the jRCTs (jRCTs072240107