Assessment of Early Left Ventricular Systolic Function in Septic Cardiomyopathy:Non-invasive Myocardial Work

Objective To investigate the clinical value of noninvasive myocardial work (MW) in assessing early left ventricular systolic dysfunction in patients with septic cardiomyopathy(SCM). Methods This prospective cohort study enrolled septic patients admitted to the EICU of Lianyungang First People's Hospital between September 2024 and May 2025. Participants were stratified into the SCM group (the study group) and the non-SCM group (the control group) based on Global Longitudinal Strain (GLS) values.Intergroup comparisons were performed: baseline clinical characteristics,conventional echocardiographic parameters. Pearson correlation analysis was employed to quantify associations between myocardial work parameters and GLS. The diagnostic value of noninvasive myocardial work parameters for SCM identification was evaluated through ROC curve. Results The study cohort comprised 84 patients, with 42 cases allocated to the SCM group and 42 to the non-SCM group. Comparative analysis revealed significantly elevated heart rate and high-sensitivity cardiac troponin I levels in the SCM group versus controls (all P < 0.05).Cardiac functional assessment demonstrated marked reductions in left ventricular ejection fraction (LVEF), GLS, global constructive work (GCW), global work efficiency (GWE), and global work index (GWI) within the SCM group compared to controls (all parameters P < 0.01).Correlation analyses identified significant negative correlations between GWI, GCW, GWE and GLS (r=-0.81, -0.71, -0.70,all P < 0.01). ROC curve confirmed the superior diagnostic performance of myocardial work indices for SCM identification, with GWI demonstrating the highest predictive value (AUC = 0.863), followed by GCW (AUC = 0.826) and GWE (AUC = 0.793). Conclusion Noninvasive myocardial work parameters demonstrate significant potential for early identification of left ventricular systolic dysfunction in SCM.