Double-Lumen Needle versus Conventional Oocyte Retrieval in IVF-ET for Diminished Ovarian Reserve (DOR): A Comparative Analysis of Clinical Outcomes

This retrospective cohort study analyzed 1,165 IVF-ET cycles of diminished ovarian reserve (DOR) patients (≤ 5 follicles > 14 mm at trigger) comparing double- versus single-lumen oocyte retrieval (559 vs 606 cycles). The double-lumen group demonstrated superior oocyte retrieval efficiency (91.06% vs 85.15%, P < 0.05) despite comparable median oocyte yield (2 [IQR 1–3] in both groups). Fresh cycles revealed significantly reduced miscarriage rates (15.38% vs 55.56%, P = 0.002) and a non-significant trend toward higher live birth rates (21.00% vs 11.49%) with double-lumen retrieval. No between-group differences were observed in fertilization success (IVF: 66.52% vs 62.30%; ICSI: 75.27% vs 70.16%), embryo quality metrics, or frozen-thawed cycle outcomes (clinical pregnancy rate: 22.93% vs 29.09%; live birth rate: 13.66% vs 18.18%, all P > 0.05). Safety profiles were equivalent between groups.The findings suggest double-lumen needles optimize follicular flushing efficacy in DOR patients, significantly reducing oocyte retention risks and fresh-cycle pregnancy loss without compromising procedural safety. While cumulative live birth rates remained unaffected, the technique's value resides in maximizing retrieval attempts for poor responders-particularly those with recurrent failure or minimal follicles. This approach may serve as a strategic adjunct in ART protocols for advanced-age populations with limited ovarian response.